Effect of gen for ?Schizophrenic Patients Treated with drug

Comparison of COMT Gene Polymorphisms and Response to ?Treatment and incidence of Extrapyramidal Side Effects in ?Schizophrenic Patients Treated with Olanzapine and Risperidone

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017012520258N29

Enrollment

Registered

2017-02-10

Start date

2014-05-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia. Organic delusional [schizophrenia-like] disorder

Interventions

Intervention 1: Intervention group: We prescribe 2-12 milligram Risperidone daily. Intervention 2: Intervention group: We prescribe 5-25 milligram Olanzapine? daily.

Treatment - Drugs

Intervention group: We prescribe 2-12 milligram Risperidone daily.

Intervention group: We prescribe 5-25 milligram Olanzapine? daily.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: schizophrenia with PANSS score more than 60; don’t use anti psychotic drug one week before; IQ more than 70; don’t use ?anti psychotic drug in 6 months ago; don’t use Electrocardiography Therapy in one month ago Exclusion criteria: psychiatric disorders in axis 1 and 2; Suicide and other plumbing; addiction in 6 ?months ago; severe drug side effects

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Response to treatment. Timepoint: after 8 week treatment. Method of measurement: PANSS form.;Extra pyramidal side effects ?. Timepoint: after 8 week treatment. Method of measurement: ESRS-A form.;Drugs side effects. Timepoint: after 8 week treatment. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr seyed Yousef Shahtaheri

Arak University of Medical Sciences

fa.farokhi@gmail.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026