Obsessive-compulsive disorder. Obsessive-compulsive disorder
Conditions
Interventions
Intervention 1: Intervention group: : Sertraline(Tab) up to 200 mg/day plus Memantine (Tab) 10mg twice per day for 12 weeks. Intervention 2: Control group: Sertraline(Tab) up to 200 mg/day plus placeb
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients who meet DSM-5 criterion for OCD and they achieve more than 21 for Yale-Brown Obsessive Compulsive Scale are suitable for study. They should be 18-65 year old and sign consent form
Exclusion criteria
Exclusion criteria: They should not be treated by any psychiatric interventions for last 6 weeks. If they show any other important mental condition or suicidal thought, neurological deficit, will exclude from study. They will be evaluated for cardiac, liver, kidney, pregnancy, lactation and mental retardation before entrance and any mentioned conditions will cause exclusion from study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of obsessive-compulsive disorder. Timepoint: Weeks: 0, 4, 8 and 12. Method of measurement: Yale-Brown Obsessive Compulsive Scale(YBOCS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Working Memory. Timepoint: Weeks: 0, 4, 8, 12. Method of measurement: Wisconsin Test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammadreza Shalbafan
Iran University of Medical Sciences
Outcome results
None listed