Granisetron for treatment of Obsessive-Compulsive Disorder

The Efficacy of Granisetron as Adjunctive Therapy in Obsessive Compulsive Disorder A Double-blind, Placebo-controlled, Randomized Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170123032145N3

Enrollment

Registered

2019-03-27

Start date

2019-04-06

Completion date

Unknown

Last updated

2019-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-compulsive disorder. Obsessive-compulsive disorder

Interventions

Intervention 1: Intervention group: Sertraline(Tab) up to 200 mg/day plus Granisetron(Tab) 1mg twice per day for 10 weeks. Intervention 2: Control group: Sertraline(Tab) up to 200 mg/day plus placebo(

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients who meet DSM-5 criterion for OCD and they achieve more than 21 for Yale-Brown Obsessive Compulsive Scale are suitable for study. They should be 18-65 years old Sign consent form

Exclusion criteria

Exclusion criteria: They should not be treated by any psychiatric interventions for 6 weeks ago. If they show any other mental important conditions or suicidal thoughts, neurological deficits, exclude from study. They will be evaluated for cardiac, liver, kidney, pregnancy, lactation and mental retardation before entrance and any mentioned conditions will cause exclusion from study.

Design outcomes

Primary

Measure	Time frame
Severity of obsessive-compulsive disorder. Timepoint: Weeks: 0, 4, 8 and 10. Method of measurement: Yale-Brown Obsessive Compulsive Scale(YBOCS).	—

Secondary

Measure	Time frame
Side effects. Timepoint: Weeks: 1, 4, 8 and 10. Method of measurement: Checklist.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammadreza Shalbafan

Iran University of Medical Sciences

Shalbafan.mr@iums.ac.ir+98 21 4450 3395

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026