Major Depressive Disorder. Major depressive disorder, single episode
Conditions
Interventions
Intervention 1: Intervention group: Citalopram tab (max. dose 20mg/day) plus L-carnosine tab 400 mg/ twice per day) for 6 weeks. Intervention 2: Control group: Citalopram tab (max. dose 20mg/day) plus
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients who meet DSM-IV-TR criterion for MDD They should be 18-60 years old and They achieve more than 18 for Hamilton Depression Scale (HamD) Sign consent form
Exclusion criteria
Exclusion criteria: Substance abuse except Nicotine for 1 year before enterance Treated by any anti-depressant medication for 1 month ago Treated by ECT for 2 months ago Presence of psychotic feature Previous diagnosed as Bipolar patient Suicidal thoughts They will evaluate for thyroid, cardiac, liver, kidney diseases, or any medical cause for depression, pregnancy, lactation before entrance and any mentioned conditions will cause exclusion from study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale score. Timepoint: 0, 2, 4, 6 weeks. Method of measurement: Hamilton Depression Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: 1,2,4,6 weeks. Method of measurement: side effects checklist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mohammadreza Shalbafan
Iran University of Medical Sciences
Outcome results
None listed