The effect of probiotics on prevention of necrotizing enterocolitis in neonates

Study of the effect of probiotics on prevention of necrotizing enterocolitis in preterm infants

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170121032075N2

Enrollment

Registered

2019-07-29

Start date

2017-08-23

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrozen enterocolitis is the most common gastrointestinal emergency in premature infants. Enterocolitis due to Clostridium difficile

Interventions

Intervention 1: Intervention group: The infants received podilactok probiotics in a dose of 1 drops per kg of body weight every 12 hours ?with breast milk or milk powder . Intervention 2: Control grou

Eligibility

Sex/Gender

All

Age

1 Days to 30 Days

Inclusion criteria

Inclusion criteria: VLBW infants (gestational age = 34 weeks and birth weight = 1500 g) survive until oral nutrition begins.

Exclusion criteria

Exclusion criteria: Severe asphyxia (stage III) Congenital major anomalies Babies who have not started oral feeding for 3 weeks after birth Infants receiving antifungal treatment

Design outcomes

Primary

Measure	Time frame
Birth weight. Timepoint: before intervention in time of birth. Method of measurement: Kilogram.	—

Secondary

Measure	Time frame
Weight. Timepoint: after intervention. Method of measurement: Kilogram.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMir Farhad Mirmohammdi

Mashhad University of Medical Sciences

mirmohammadif951@mums.ac.ir+98 51 3852 1121

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026