Stroke. Vascular syndromes of brain in cerebrovascular disease
Conditions
Interventions
Intervention 1: Intervention:
1. Amp N- acetyl- cysteine 100 mg/kg stat in the onset of stroke then 10 mg/kg/hour IV infusion for 10 hours. Intervention 2: Intervention:
2. Tab ASA 325 mg PO daily fo
Treatment - Drugs
Intervention:
1. Amp N- acetyl- cysteine 100 mg/kg stat in the onset of stroke then 10 mg/kg/hour IV infusion for 10 hours.
Intervention:
2. Tab ASA 325 mg PO daily for 14 days then 80 mg PO daily lifelong
Intervention:
3. Tab plavix 325 mg PO stat then 75 mg daily for 90 days
Control:
2. Tab plavix 325 mg PO stat then 75 mg daily for 90 days
Control:
1. Tab ASA 325 mg PO daily for 14 days then 80 mg PO daily lifelong
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: all admitted patients with first attack of mild to moderate CVA according to NIHSS between 0-16; admitted patients within first 24 hours of onset of CVA. Exclusion criteria:Hemorrhagic stroke; Severe Hepatic or renal failure. ( creatinine clearance less than 30 mg/dl); History of Vasculitis; Allergy to N- acetyl- cystein; Alzheimer or dementia due to any cause; Coexistent other neurologic disorders.;Past history of CVA;Age more than 80 years; Diseases that affect on MMP-9 level. e.g neuropsychiatric disorders like schizophrenia and bipolar disorder,epilepsy and mutiple sclerosis; Intravenous or intaarterial r-tPA injection.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMP9. Timepoint: Before and 24 hours after intervention. Method of measurement: ELISA kit.;NIHSS. Timepoint: Before intervention, 24 hours, 2 weeks, 1 month and 3 months after intervention. Method of measurement: Standard scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: 24 hours after treatment. Method of measurement: Clinic. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRezan ashayeri
Iran University of Medical Sciences
Outcome results
None listed