Nausea and vomiting afterstabismus surgery

Clinical trial forcomparing of Ondansetrone, Metoclopramide And Midazolam for PONV prophylaxis in patients undergoing Strabismus surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017011920588N5

Enrollment

160

Registered

2017-06-30

Start date

2017-01-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and vomiting. Diseases of oesophagus, stomach and duodenum

Interventions

Intervention 1: Intervention Group : " ON" group will receive Ondansetrone 0.05 mg/kg. Intervention 2: Placebo Group : "CT" group will receive the solution of NACL 0.9% as Placebo. Intervention 3: In

Prevention

Treatment - Drugs

Intervention Group : " ON" group will receive Ondansetrone 0.05 mg/kg.

Placebo Group : "CT" group will receive the solution of NACL 0.9% as Placebo.

Intervention group : " MT" group will receive Metoclopramide 0.15 mg/kg intravenously.

Intervention group :" MD" group will receive Midazolam 0.03 mg/kg Intravenously.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : All candidates of strabismus surgery under general anesthesia with American Society Of Anesthesiologists (ASA) class I-II. Exclusion Criteria : Documented psychiatric disorders; any hypersensitivity to Ondansetrone, Metoclopramide or Midazolam; history of opium, alcohol, cigarette or benzodiazepines addiction? BMI over 25; pregnancy; chronic cough; history of malignant hyperthermia; history of using of any anti emetic drug 24 hours before surgery;Any event causing change in anesthesia technique or ICU admission or death of the patient.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Vomiting. Timepoint: In recovery, first and second 6 hours and 12 hour s later. Method of measurement: Frequency.;Nausea. Timepoint: iIn Recovery, First And Second 6 Hours And 12 Hours Later. Method of measurement: VAS (visual analogous score).	—

Secondary

Measure	Time frame
First time of solid and liquid diet toleranse. Timepoint: During the first 24 hours after anesthesia. Method of measurement: Hour.;Total dose of antiemetic drug used. Timepoint: During The First 24 Hours After Anesthesia. Method of measurement: Milligram.;Drug complications. Timepoint: During The First 24 Hours After Anesthesia. Method of measurement: Frequency.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDarioush Moradi Farsani

Isfahan University Of Medical Sciences

dmoradi@med.mui.ac.ir+49 31362 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026