Delirium. Delirium, not induced by alcohol and other psychoactive substances
Conditions
Interventions
Intervention 1: Intervention: Tablet aripiprazole 15 mg daily orally for seven days. Intervention 2: Control: Tablet placebo once daily for 7 days.
Treatment - Drugs
Placebo
Intervention: Tablet aripiprazole 15 mg daily orally for seven days
Control: Tablet placebo once daily for 7 days
Sponsors
Shahid Beheshti University of Medical Science
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 18-80 yo patients admitted to intensive care unit Exclusion criteria: pregnancy; breastfeeding; preexisting active delirium; bradycardia (heart rate <60); alcohol intoxication; liver failure (Child Pough Score: sever); kidney failure(GFR<15); history of anti-psychotic drug(s); ICU stay less than 3 days
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Delirium incidence. Timepoint: Entrance to study, Daily for 7 days. Method of measurement: Evaluation of CAM-ICU score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug effect on Lipid profile. Timepoint: Day 0 and 7. Method of measurement: Blood sample.;Drug effect on blood sugar. Timepoint: Daily. Method of measurement: Blood sample.;Drug effect on liver function tests. Timepoint: Day 0 and 7. Method of measurement: Blood sample.;Drug effect on ICU stay. Timepoint: Daily. Method of measurement: Counting the Admission days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Sistanizad
Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences
Outcome results
None listed