Effect of Silymarine on prognosis and survey in patients with traumatic brain injury

Effect of Silymarine on prognosis and survey in patients with severe ?and moderate traumatic brain injury

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017011720258N27

Enrollment

Registered

2017-02-12

Start date

2015-07-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

traumatic brain injury. Focal brain injury

Interventions

Intervention 1: Intervention group: We prescript standard treatment and Silymarine 140 milligram oral (oral ?and gavage)every 8 hours for 7 days. Intervention 2: In control group: We prescript standar

Treatment - Drugs

Intervention group: We prescript standard treatment and Silymarine 140 milligram oral (oral ?and gavage)every 8 hours for 7 days.

In control group: We prescript standard treatment and placebo.

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 18-65 years; patients with severe ?and moderate traumatic brain injury (Glasgow Coma Scale less than 12) Exclusion criteria: Morbidity in first 7 days; patients with surgery brain in admission; addiction; severe traumatic injury in other parts of the body

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Consciousness in patients. Timepoint: Before and after surgery. Method of measurement: Glasgow Coma Scale.;Mortality. Timepoint: In duration 3 months after surgery. Method of measurement: Question.;Morbidity. Timepoint: 3 months after surgery. Method of measurement: Question.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Ali Nazemi Rafie

Arak University of Medical Sciences

nazemi@arakmu.ac.ir+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026