The effect of laser therapy on gingival inflammation

Comparison of the effect of low power Diode laser therapy and placebo on the amount of Interleukin 1 beta in gingival crevicular fluid after placement separators in orthodontic patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017011620523N2

Enrollment

Registered

2017-02-25

Start date

2017-02-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingival inflammation. Gingivitis and periodontal diseases

Interventions

Intervention 1: Intervention 1: Irradiation of Diode laser with 980 nanometer wavelength and 1.5 Watts power with pulse irradiation with pulse length of 1 millisecond and pulse distance of 1 milliseco

Treatment - Other

Placebo

Intervention 1: Irradiation of Diode laser with 980 nanometer wavelength and 1.5 Watts power with pulse irradiation with pulse length of 1 millisecond and pulse distance of 1 millisecond on buccal and

Irradiation of off laser with the same movement on buccal and lingual surface of maxillary first molar

Eligibility

Sex/Gender

All

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Signing informed consent; Absence of active periodontal disease (probing depth less than 4 mm and lack of bleeding on probing in upper first molars); Absence of systemic disease. Exclusion criteria: Presence of coagulation disease; Presence of acute or chronic disease (Based on patient chart); Presence of auto-immune disease; Patients under immune-suppressive therapy or radiotherapy; Patients who consume antibiotics; Patients who consume corticosteroids or nonsteroidal anti-inflammatory drugs (NSAIDS); Pregnant women. 8. Patients under periodontal treatment or prolonged consumption of chlorhexidine

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Amount of interleukin 1 beta in gingival crevicular fluid. Timepoint: Before placement of separator and 1 week later. Method of measurement: ELISA on gingival crevicular fluid.	—

Secondary

Measure	Time frame
Bleeding point index. Timepoint: Before placement of separator and 1 week later. Method of measurement: Occurence of bleeding during the movement of periodontal probe in gingival sulcus.;Gingival index. Timepoint: Before placement of separator and 1 week later. Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSepideh Soheilifar

Hamedan University of Medical Sciences

se.soheilifar@gmail.com+98 81 3822 3750

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026