Effects of caffeine and aerobic training on type 2 diabetes

The effects of supplementation with caffeine alone and in combination with aerobic training on some insulin resistance indices in patients with type 2 diabetes: a double-blind and placebo-controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170116031982N2

Enrollment

Registered

2020-04-24

Start date

2020-06-20

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Intervention group: The first intervention group 8 weeks of walking on the treadmill with a slope of zero degrees for 40 minutes with an intensity of 70-60% heart rate reserve for thre

Eligibility

Sex/Gender

Male

Age

50 Years to 55 Years

Inclusion criteria

Inclusion criteria: Fasting blood sugar between 250-125 mg / dL Lack of diabetes-related diseases (such as neuropathy, nephropathy, retinopathy) Lack of regular participation in regular phusical activities more than one session per week during the last 3 months No blood pressure above 140/90 mm Hg

Exclusion criteria

Exclusion criteria: Complications of diabetes such as diabetic foot History of cardiovascular disease

Design outcomes

Primary

Measure	Time frame
Leptin. Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: The double-antibody sandwich ELISA.;Adiponectin. Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: ELISA.	—

Secondary

Measure	Time frame
Glucose. Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: Glucose oxidase methods.;Insulin. Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: Competitive ELISA.;Homeostatic model assessment (HOMA). Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: Fasting serum insulin (µU/ml) × fasting plasma glucose (mmol/l)/22.5.;Quantitative Insulin Sensitivity Check Index. Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: 1/ (log(fasting insulin µU/mL) + log(fasting glucose mg/dL))=QUICKI.	—

Measure

Time frame

Glucose. Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: Glucose oxidase methods.;Insulin. Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: Competitive ELISA.;Homeostatic model assessment (HOMA). Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: Fasting serum insulin (µU/ml) × fasting plasma glucose (mmol/l)/22.5.;Quantitative Insulin Sensitivity Check Index. Timepoint: The first stage before the start of supplementation and training and the second stage 24 hours after the last training session. Method of measurement: 1/ (log(fasting insulin µU/mL) + log(fasting glucose mg/dL))=QUICKI.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBahram jamali garakhanlu

Tabriz University of Medical Sciences

jamalib@tbzmed.ac.ir+98 41 3335 7580

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026