effect of phytosterols on non alcoholic fatty liver disease

Effect of phytosterols supplementation on serum levels of inflammatory markers ,liver enzymes ,lipid profiles ,Adiponectin ,Leptin and fasting blood sugar in non-alcoholic fatty liver disease patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017011531958N1

Enrollment

Registered

2017-02-20

Start date

2017-02-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non Alcoholic Fatty liver Disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group : daily consumption of 400 mg phytosterols supplement (twice a day and each time 2 tabs=1.6 g) for 60 days. Intervention 2: control group : daily consumption of 400

Treatment - Drugs

Placebo

Intervention group : daily consumption of 400 mg phytosterols supplement (twice a day and each time 2 tabs=1.6 g) for 60 days

control group : daily consumption of 400 mg starch (twice a day and each time 2 tabs=1.6 g) for 60 days

Eligibility

Sex/Gender

All

Age

19 Years to 59 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 19-59 years old patient with non alcoholic fatty liver disease Exclusion criteria: Patients who have diabetes, cardiovascular, kidney and other hepatic diseases; Pregnant or lactating women; Smoking; Alcohol consumption; Use of dietary supplements

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Aspartate aminotransferase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Alanine aminotransferase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Gamma-glutamyl transpeptidase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Interlukine-6. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Hs-CRP. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;TNF-a. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Total cholestrol. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;LDL-C. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;HDL-C. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Triglyciride. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;VLDL. Timepoint: Before intervention and 2 months after intervention. Method of measurement: TG/5.;Adiponectin. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Leptin. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Fasting blood sugar. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.	—

Measure

Time frame

Aspartate aminotransferase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Alanine aminotransferase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Gamma-glutamyl transpeptidase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Interlukine-6. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Hs-CRP. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;TNF-a. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Total cholestrol. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;LDL-C. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;HDL-C. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Triglyciride. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;VLDL. Timepoint: Before intervention and 2 months after intervention. Method of measurement: TG/5.;Adiponectin. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Leptin. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.;Fasting blood sugar. Timepoint: Before intervention and 2 months after intervention. Method of measurement: blood test.

—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By manometer according to mmHg.;Body weight. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Digital scale.;Body mass index. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Body weight in kilograms divided by height squared in meters.;Waist circumference. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By measuring tape according to meter.;Hip circumference. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By measuring tape according to meter.	—

Measure

Time frame

Blood pressure. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By manometer according to mmHg.;Body weight. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Digital scale.;Body mass index. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Body weight in kilograms divided by height squared in meters.;Waist circumference. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By measuring tape according to meter.;Hip circumference. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By measuring tape according to meter.

—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmohammad ali javanmardi

School of Paramedicine, Ahvaz Jondishapur University Of Medical Sciences

javanmardi.m@ajums.ac.ir//soroush.javanmardi@yahoo.com+98 61 3333 3050

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026