The effect of letrozole in combination with misoprostol on induced abortion success rate

Evaluation of effect of letrozole with misoprostol in comparison with misoprostol alone in success rate of induced abortion

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017011526962N3

Enrollment

Registered

2017-02-10

Start date

2017-01-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

induced abortion. Pregnancy with abortive outcome

Interventions

Administration of misoprostol alone

Intervention 1: In intervention group the patients will receive 10 mg/kg letrazole and 4 vaginal tablets (200 µg) of misoprostol for 3 dose. Intervention 2: Administration of misoprostol alone.

Treatment - Drugs

In intervention group the patients will receive 10 mg/kg letrazole and 4 vaginal tablets (200 µg) of misoprostol for 3 dose

Eligibility

Sex/Gender

Female

Age

18 Years to 38 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients more than 18 years of age, pregnancy in 14 or less than 14 weeks (will be on firmed by ultrasonography), Hb above 10, diastolic blood pressure of below 95 mm Hg Exclusion criteria: Adrenal gland failure, cancer, porphyria, thromboembolism, severe hepatic diseases, bronchial asthma, hypertension, breast feeding, hepatic function tests disorders, blood tests disorders, consumption of any medicine

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Complete abortion. Timepoint: After intervention. Method of measurement: will be on firmed by ultrasonography.;The duration of induction to complete expulsion of products of conception. Timepoint: The interval between the consumer misoprostol l until the abortion. Method of measurement: Hours.	—

Secondary

Measure	Time frame
The need for surgical abortion in the two groups. Timepoint: During intervention. Method of measurement: will be on firmed by ultrasonography.;The consumer misoprostol in two groups. Timepoint: During intervention. Method of measurement: The number of vaginal tablets used.;Age patients. Timepoint: During intervention. Method of measurement: Year.;Gestational age. Timepoint: The duration from the last period. Method of measurement: Week.	—

Measure

Time frame

The need for surgical abortion in the two groups. Timepoint: During intervention. Method of measurement: will be on firmed by ultrasonography.;The consumer misoprostol in two groups. Timepoint: During intervention. Method of measurement: The number of vaginal tablets used.;Age patients. Timepoint: During intervention. Method of measurement: Year.;Gestational age. Timepoint: The duration from the last period. Method of measurement: Week.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactTahereh Behroozi Lak

Urmia University of Medical Sciences

behroozilak.t@umsu.acir+98 44 3223 7077

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026