pain. Acute pain
Conditions
Interventions
Intervention 1: Intervention group 1: 1.0 mg/kg of diluted morphine will be administered intravenously and 5 cc of sterile water will be given via nebulizer as placebo. Pain and drug side effects will
Treatment - Drugs
Intervention group 1: 1.0 mg/kg of diluted morphine will be administered intravenously and 5 cc of sterile water will be given via nebulizer as placebo. Pain and drug side effects will be evaluated 0,
Intervention group 2: 2.0 mg/kg of nebulized morphine sulfate is administered via facemask, and 5 cc of sterile water is given via nebulizer as placebo. Pain and drug side effects will be evaluated 0,
Intervention group 3: 4.0 mg/kg of nebulized morphine sulfate is administered via facemask and 5 cc of sterile water is given via nebulizer as placebo. Pain and drug side effects will be evaluated 0,
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria were: age between 18 and 65 years; severe acute musculoskeletal pain between 6 and 10 on VAS. Exclusion criteria: Consent to participate in research projects; Drug addiction; Systolic blood pressure less than 90 mmHg; GCS less than 15; Heart, lung, kidney, liver or mental diseases; Pregnancy and lactation; Known hypersensitivity to morphine and ketamine.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: 0, 15 , 30, 45 and 60 minutes after intervention. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypotension. Timepoint: 0, 15, 30, 45 and 60 minutes after intervention. Method of measurement: Blood pressure cuff.;Apnea. Timepoint: 0 , 15, 30, 45 ,and 60 minutes after intervention. Method of measurement: puls oximetry.;Oxygen saturation. Timepoint: 0 , 15, 30, 45 , and 60 minutes after intervention. Method of measurement: puls oximetry.;Nausea and vomiting. Timepoint: 0 , 15, 30, 45 and 60 minutes after intervention. Method of measurement: Observation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Dashti
Iran University of Medical Sciences
Outcome results
None listed