Effect of sertraline and melatonin on tinnitus

A clinical trial to compare the effect of sertraline and melatonin on the treatment of tinnitus

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2017011412782N13

Enrollment

Registered

2017-03-30

Start date

2015-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tinnitus. Tinnitus

Interventions

Intervention 1: Intervention group: patients are treated by sertraline, 50 mg oral tablet, once a day for 3 months. Intervention 2: Control group: patients are treated by Melatonin 3 mg oral tablet, o

Treatment - Drugs

Intervention group: patients are treated by sertraline, 50 mg oral tablet, once a day for 3 months.

Control group: patients are treated by Melatonin 3 mg oral tablet, once a day for 3 months.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: tinnitus for at least 6 months; normal audiogram test; possibility of follow up; Insensitivity to sertraline, melatonin and benzodiazepine compounds and agreement to participate in this study. Exclusion criteria: patients who have tinnitus with specific etiology or have a history of recent head trauma.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Tinnitus. Timepoint: before intervention and three months after intervention. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Mahdi Mahmoodi

Isfahan University of Medical Sciences

Dr.mahdi.mahmoodi@gmail.com+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026