migraine.
Conditions
Interventions
Intervention 1: After the eligibility criteria will be applied, 112 chronic migraineurs will be selected and randomly allocated to placebo or intervention groups. Upon admission, a headache questionna
Treatment - Drugs
Placebo
After the eligibility criteria will be applied, 112 chronic migraineurs will be selected and randomly allocated to placebo or intervention groups. Upon admission, a headache questionnaire will be give
Sponsors
Iranian Center of Neurological Research, Tehran University of Medical Sciences,
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patients will be included in the study due to the following inclusion Criteria: having = 15 headache days per month for at least 3 months, history of migraine for at least 1 year, age 18-45 years, systolic blood pressure between 110-140 mmHg Taking a large amount of abortive drugs. The exclusion criteria were as follows: having psychiatric illness, having major neurological disorders and / or other chronic or systemic diseases, being pregnant or have a planned pregnancy, breastfeeding, taking prophylactic medications in the last 4 weeks, suffering from impaired liver function or kidney disorders, allergies to ACE inhibitors, history of angionearotic edema suffering from secondary headaches.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Migraine headache severity. Timepoint: first month, second month, third month. Method of measurement: Visual Analog Scale (VAS).;Migraine headache duration. Timepoint: first month, second month, third month. Method of measurement: Migraine headache diary.;Migraine headache frequency. Timepoint: first month, second month, third month. Method of measurement: Migraine headache diary. | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission from Chronic Migraine to Episodic Migraine. Timepoint: first week, second month. Method of measurement: physical examination, headache diary. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactProf. Mansoureh Togha
Sina Hospital, Tehran University of Medical Sciences
Outcome results
None listed