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The impact of sedation protocol on some clinical outcomes of mechanically ventilated patients

The impact of sedation protocol using Richmond Agitation-Sedation Scale (RASS) on some clinical outcomes of mechanically ventilated patients in the Intensive Care Unit (ICU): A Clinical Trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2017010831824N1
Enrollment
90
Registered
2017-11-06
Start date
2017-01-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation. Persons encountering health services for specific procedures, not carried out

Interventions

Intervention 1: In the proposed protocol, the sedation level of patients will be assessed and recorded using RASS Scale each hour, at the same time of assessment of patients' vital signs by nurses. No
otherwise, the RASS Scale will be applied and the sedative drugs will be administered according to the patient’s medication order. Intervention 2: The control group will receive the routine treatment
Treatment - Drugs
In the proposed protocol, the sedation level of patients will be assessed and recorded using RASS Scale each hour, at the same time of assessment of patients' vital signs by nurses. No particular inte
otherwise, the RASS Scale will be applied and the sedative drugs will be administered according to the patient’s medication order.
The control group will receive the routine treatment and sedation according to the patients' physiological reactions and nurses' clinical judgment to control pain.

Sponsors

Vice chancellor for research Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Intubated patient; need to have mechanical ventilation; no addiction (according to patient records and information from patient attendants); Range of age: between 15 and 65; RASS score higher than -3 scores; and GCS score between 5 and 13. Exclusion criteria: consciousness and extubation during first 24 hours; changing prescribed medicine by the physician; stopping the sedative prescribed medicine; transferring to the operating room; dramatical decrease in the level of patient's consciousness; continuous sedative infusion.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Duration of mechanical ventilation. Timepoint: Daily. Method of measurement: Counting hospitalization days.

Secondary

MeasureTime frame
Death. Timepoint: Daily. Method of measurement: Patient's records.;Duration of hospitalization at Intensive Care Unit. Timepoint: At the end of hospitalization at Intensive Care Unit. Method of measurement: Counting the hospitalization days.;Transferring from the ICU to the ward. Timepoint: Daily. Method of measurement: Patient's records.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Taran

Zanjan University of Medical Sciences

zahra.taran93@gmail.com+98 24 3355 2985

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026