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Evaluation of the effects of hydrocortisone on hemodynamic changes in patients under general anesthesia

Comparison of the effectiveness of hydrocortisone and placebo (distilled water) on hemodynamic changes in atracurium for intubation in patients with upper limb fractures (candidate for elective surgery)

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20170108031818N2
Enrollment
48
Registered
2022-04-20
Start date
2022-04-30
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients for elective surgery for upper limb fractures. Fracture of upper limb, level unspecified

Interventions

Intervention 1: Intervention group: Individuals in the hydrocortisone group receive 100 mg of hydrocortisone intravenously and bolus with 300 ml of normal saline under the supervision of a nurse who

Sponsors

Gorgan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 60 Years

Inclusion criteria

Inclusion criteria: All patients for elective surgery between the ages of 15-60 with ASA I or II

Exclusion criteria

Exclusion criteria: All patients for elective surgery between the ages of 15-60 with ASA I or II Metabolic and neuromuscular disorders People if they receive strong antibiotics effective on the effects of relaxants, including aminoglycosides 24 hours before surgery Significant liver and kidney disease Known allergies to narcotics and other drugs used during anesthesia if he took the H1 histamine blocker the day before surgery Obesity (if ideal body weight> 30)

Design outcomes

Primary

MeasureTime frame
Hemodynamic changes. Timepoint: Hemodynamics will be recorded in the relevant list before the administration of hydrocortisone and 30 minutes after the administration of hydrocortisone or at the entrance to the operating room and 5 minutes after the peak effect of atracurium (before intubation) and after ecstasy. Method of measurement: This monitoring will be performed under the supervision of an anesthesiologist based on patient monitoring instructions, including continuous monitoring of heart rate, arterial oxygen saturation and intermittent and non-invasive measurement of systolic and diastolic blood pressure and bronchospasm by Saadat's monitoring device.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactKazem Kazemnejad Tabrizi

Gorgan University of Medical Sciences

mehravar10261@yahoo.com+98 17 3223 8363

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026