Acute Respiratory Distress Syndrome. Acute Respiratory Distress Syndrome
Conditions
Interventions
Intervention 1: In the first group of intervention
the intervention is the injection of 1 million stromal cells of embryonic membranes intravenously in 30 minutes. Intervention 2: In the second group of intervention
the intervention is the injection of 2 million stromal cells of embryonic membranes intravenously in 30 minutes. Intervention 3: In the third group of intervention
the intervention is the injection of 5 million stromal cells of embryonic membranes intravenously in 30 minutes.
Treatment - Drugs
In the first group of intervention
the intervention is the injection of 1 million stromal cells of embryonic membranes intravenously in 30 minutes.
In the second group of intervention
the intervention is the injection of 2 million stromal cells of embryonic membranes intravenously in 30 minutes.
In the third group of intervention
Sponsors
Breast Cancer Research Center (BCRC), Motamed Cancer Institute, Tehran University of Medical science
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients over 18 years of age; Diagnosis is done by Berlin definition; The disease is acute; Bilateral lungs with pulmonary edema are evident on X-ray; The patient does not have a history of heart failure; PaO02 / FiO2 less than 200 while the patient is under mechanical ventilation via endotracheal tube or tracheostomy tube with positive end-expiratory pressure at least 8 inches of water; A fungal infection does not exist. Exclusion criteria: If three days have passed from the onset of the disease; Any disease history of the vital organs such as heart disease, kidney or liver; Pregnancy; Pulmonary hypertension; Cancer; AIDS; seronegative for hepatitis A and B; seronegative for syphilis; Symptoms of pulmonary embolism.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dose of third vasopressor. Timepoint: 6 hours after injection. Method of measurement: 1-Norepinephrine: 10 µg per min 2- Phenylephrine: 100 µg per min 3- Dopamine: 10 µg / kg per min 4- Epinephrine: 0 - 1 µg / kg per min in serum.;Hypoxemia. Timepoint: 6 hours after injection. Method of measurement: FiO2 =0.2 or PEEP = 5 cmH2O or more.;Occurrence cardiogenic cardiac or ventricular arrhythmia. Timepoint: 6 hours after injection. Method of measurement: Clinical examination and electrocardiogram. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac arrest or death. Timepoint: 24 hours after injection. Method of measurement: Clinical Examination.;Septicemia. Timepoint: 6 hours after injection. Method of measurement: Base on urine and blood laboratory examination.;Rapid clinical instability after injection in the cardiovascular and respiratory systems. Timepoint: 30 min after injection. Method of measurement: Change in systolic or diastolic blood pressure, mean arterial blood pressure changes.;Drug toxicity. Timepoint: 30 min after injection. Method of measurement: Pulmonary embolism, fever, respiratory inflammation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehnam Sadeghi
Breast Cancer Research Center (BCRC), Motamed Cancer Institute, Tehran University of Medical Science
Outcome results
None listed