Two very low doses of naloxone in combination with ropivacaine on the onset ,severity and duration of axillary block

Comparison of two very low doses of naloxone in combination with ropivacaine on the onset ,severity and duration of axillary block in patients with hand and forearm surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20170105031787N6

Enrollment

Registered

2023-05-03

Start date

2023-05-22

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hand and forearm surgery. Injuries to the elbow and forearm

Interventions

Intervention 1: Intervention group 1: The axillary block will be performed using 29 cc of ropivacaine 0.5% (manufacturer: Varian Pharmamed) plus 1 cc of naloxone 4 micrograms (manufacturer: Tolid Daro

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Candidate patients for hand and forearm surgery Age between 18-70 years

Exclusion criteria

Exclusion criteria: Anemia Sensitivity to local anesthetic drugs Congenital and acquired neuromuscular diseases History of seizures Drug addiction Heart diseases Any digestive system disorders.

Design outcomes

Primary

Measure	Time frame
Pain score. Timepoint: Upon entering recovery. Method of measurement: Based on NRS scale.;The amount of drug use. Timepoint: In the first 24 hours after the surgery. Method of measurement: Based on the information in the patient's file.	—

Secondary

Measure	Time frame
Duration of numbness. Timepoint: During surgery. Method of measurement: Based on the information in the patient's file.;The first time to ask for drugs. Timepoint: During surgery. Method of measurement: Based on the information in the patient's file.;Ramsy sedation scale. Timepoint: During surgery and upon entering recovery. Method of measurement: Based on the information in the patient's file.;Patient's satisfaction. Timepoint: After surgery. Method of measurement: Based on the Likert scale.	—

Measure

Time frame

Duration of numbness. Timepoint: During surgery. Method of measurement: Based on the information in the patient's file.;The first time to ask for drugs. Timepoint: During surgery. Method of measurement: Based on the information in the patient's file.;Ramsy sedation scale. Timepoint: During surgery and upon entering recovery. Method of measurement: Based on the information in the patient's file.;Patient's satisfaction. Timepoint: After surgery. Method of measurement: Based on the Likert scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahshad Ghezel Bash

Iran University of Medical Sciences

Mahshad.ghezelbash@gmail.com+98 21 6435 2491

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026