Condition 1: Chronic obstructive pulmonary disease. Condition 2: Pneumonia. Chronic obstructive pulmonary disease with acute exacerbation, unspecified Pneumonia, unspecified
Conditions
Interventions
Intervention 1: In the case group, the antibiotic therapy is guided by serum procalcitonin. In this group, the patients are classified into four groups, according to the procalcitonin algorithm that i
Treatment - Other
Treatment - Drugs
In the case group, the antibiotic therapy is guided by serum procalcitonin. In this group, the patients are classified into four groups, according to the procalcitonin algorithm that is validated in p
In the control group, the antibiotic therapy is chosen on the basis of usual practice guidelines.
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients to be at least 18 years; with diagnosis of Community Acquired Pneumonia ( CAP ) or Chronic Obstructive Pulmonary Disease ( COPD ) exacerbation; with at least one respiratory symptom ( cough, sputum, dyspnea, tachypnea, pleuretic chest pain ); in addition to at least one respiratory sign on auscultation (rales,cripitation); or one infection indicator ( T greater than 38 c, chills, WBC less than 4000 or greater than 10000 per milliliter ); hospitalized in Infectious ward of Arak Valiasr University Hospital. Exclusion criteria: Patients that can't consent voluntary; active IV drug users; severe immunosuppression ( except use of corticosteroid ); severe comorbidity; patients with hospital- acquired pneumonia ( pneumonia presented at 48 hours after hospitalization or previous history of hospitalization during 14 days before this admission ); patients requiring antibiotic therapy for chronic infection.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of hospitalization. Timepoint: 14 days after intervention. Method of measurement: day.;Duration of treatment. Timepoint: 14 days after intervention. Method of measurement: day. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Results. Timepoint: 3, 5, 7, 14 days after intervention. Method of measurement: Clinical assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNaghmeh Arkan
School of Medicine, Arak University of Medical Sciences
Outcome results
None listed