Mechanical Ventilation. Other postprocedural respiratory disorders
Conditions
Interventions
Intervention 1: Intervention group: Patients in drug group will receive heparin 10000 Iu every 6 hours via nebulization for 5 days. Both groups will receive all other standard treatments. Interventio
Treatment - Drugs
Intervention group: Patients in drug group will receive heparin 10000 Iu every 6 hours via nebulization for 5 days. Both groups will receive all other standard treatments
Control group: Patients will receive standard treatment.
Sponsors
Vice Chancellor for Research,Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients who require invasive mechanical ventilation for more than 48 hours. Exclusion criteria:If patients receive mechanical ventilation for more than 24 hours prior to enrollment; has required mechanical ventilation for more than 48 hours in previous admission in ICU during the current hospital admission; allergy to heparin (including any history of heparin-induced thrombocytopenia); a pulmonary hemorrhage in the previous 3 months; uncontrolled bleeding or a significant bleeding disorder; an intracranial hemorrhage in the past 12 months; or an epidural catheter in place or likely to be placed in the next 48 hours and are younger than 18 years old.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in ratio of partial pressure of oxygen to FiO2 (PaO2/FiO2). Timepoint: during the 5 days of study. Method of measurement: ratio of PaO2/FiO2. | — |
Secondary
| Measure | Time frame |
|---|---|
| (RSBI)RAPID SHALLOW BREATHING INDEX. Timepoint: during 5 days of study. Method of measurement: ratio of tidal volume to respiratory rate. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sarah Mousavi
Isfahan University of Medical Science
Outcome results
None listed