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Effect of prolotherapy with hypertonic dextrose versus hypertonic saline on knee osteoarthritis

Evaluation of the effectiveness of prolotherapy with hypertonic dextrose versus hypertonic saline on patients with knee osteoarthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016122931458N1
Enrollment
60
Registered
2017-02-06
Start date
2017-01-20
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee. Gonarthrosis [arthrosis of knee]

Interventions

Intervention 1: Intervention group: Intra-articular injection with 4mL of 50% dextrose and 4mL of 2% lidocaine. Intervention 2: Control group: Intra-articular injection with 4mL of 5% Sodium Chloride
Treatment - Drugs
Intervention group: Intra-articular injection with 4mL of 50% dextrose and 4mL of 2% lidocaine
Control group: Intra-articular injection with 4mL of 5% Sodium Chloride and 4mL of 2% lidocaine

Sponsors

Shiraz University Of medical Science
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients with osteoarthritis of knee who experience joint symptoms (pain, stiffness and reduced function) during one recent month; aged between 40-70 years. Exclusion criteria: rheumatology diseases; radiculopathy; history of trauma and fracture in knees; diabetes; coagulopathy disorders; pregnant women; body mass index (BMI) more than 42.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Questionnaire of Visual Analog Scale. Timepoint: Before intervention, 2 weeks after intervention, 4 weeks after intervention. Method of measurement: Questionnaire.

Secondary

MeasureTime frame
Questionnaire of Western Ontario & McMaster Universities Osteoarthritis Index. Timepoint: Before intervention, 2 weeks after intervention, 4 weeks after intervention. Method of measurement: Questionnaire.;Questionnaire of Oxford Knee Scale. Timepoint: Before intervention, 2 weeks after intervention, 4 weeks after intervention. Method of measurement: Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Reza Farpour

Shiraz University of Medical Sciences

farporh@sums.ac.ir+98 71 3623 4504

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026