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The effect of a single dose of sublingual misoprostol on blood loss in total abdominal hysterectomy in patients with uterine myoma

The effect of a single dose of sublingual misoprostol on blood loss in total abdominal hysterectomy in patients with uterine myoma

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016122831635N1
Enrollment
100
Registered
2017-06-09
Start date
2017-04-04
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

uterine myoma. Disorder of uterus NOS

Interventions

Intervention 1: Intervention group: Fifty women who will Receive one pack of Misoprostol (400µg) before surgery. Intervention 2: control group are 50 women who will receive one pack of Placebo before
Treatment - Drugs
Intervention group: Fifty women who will Receive one pack of Misoprostol (400µg) before surgery.
control group are 50 women who will receive one pack of Placebo before surgery.

Sponsors

Vice chancellor for research, Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients who choose to be treated by TAH with BSO or without BSO; Their last delivery was 24 months ago or before. Exclusion criteria: History of pelvic surgery; Severe heart or lung disease; Hematologic Disorders; Glaucoma; Asthma; liver disease; Endometriosis; Adnexal masses; history of myomectomy; Those who have taken GnRH agonist before surgery; allergy to misoprostol, Diastolic pressure above 100.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Changes of Hemoglobin. Timepoint: 24 hours after interventional. Method of measurement: complete blood count.

Secondary

MeasureTime frame
Bleeding during surgery. Timepoint: during surgery. Method of measurement: The amount of blood inside the suction device , The gravity of bloody sponges.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactdr. Salme Dadgar

Mashhad University of Medical Sciences

dadgars@mums.ac.irwhrc@mums.ac.ir+98 51 3802 2608

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026