cardiovascular disease. Certain current complications following acute myocardial infarction
Conditions
Interventions
Intervention 1: In group I, before performing PCI, if caught thrombosis in (180 micrograms per kilogram) coronary arteries, patients received two boluses of eptifibatide through the guiding catheter i
Treatment - Drugs
In group I, before performing PCI, if caught thrombosis in (180 micrograms per kilogram) coronary arteries, patients received two boluses of eptifibatide through the guiding catheter in the infarct-re
In group II or intralesional administration group boluses of eptifibatide(180 micrograms per kilogram) is administered through the export aspiration catheter into the lesion of infarct-related artery
Sponsors
Vice Chancellor for research of Isfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Diagnosis of ST elevation myocardial infarction (STEMI) as defined by chest pain suggestive for myocardial ischemia for at least 30 minutes before hospital admission and symptoms onset time was less than 12 hours with 1 mm ST segment elevation in 2 or more contiguous leads (for V1-V3 ST elevation was 2 mm) simultaneously; These patients should also have three or more thrombus burden grade on the angiography. Thrombus burden was graded (G) as G0 = no thrombus, G1 = possible thrombus, G2 = small (greatest dimension = 1/2 vessel diameter), G3 = moderate (> 1/2 but < 2 vessel diameter), G4 = large (= 2 vessel diameter), G5 = unable to assess TB due to vessel occlusion; undergoing PCI; The consent of patients or their families to participate in the study; insensitivity to Eptifibatide Exclusion criteria: Rescue PCI after thrombolytic therapy; Contraindications for antiplatelet such as bleeding disorder including gastrointestinal bleeding, hematuria, or known any bleeding tendency; thrombocytopenia (Platelet count<100.000/cm3); recent stroke (less than 6 months) and cardiogenic shock
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thrombolysis in myocardial infarction (TIMI) flow. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: TIMI flow grading.;Myocardial blush grade (MBG). Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: Myocardial blush grading.;No-reflow phenomenon. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: TIMI flow grading and Myocardial blush grading. | — |
Secondary
| Measure | Time frame |
|---|---|
| Re myocardial infarction. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: ECG.;Heart failure. Timepoint: during hospitalization. Method of measurement: Eco cardiography.;Arrhythmia. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: ECG.;Ventricular systolic function. Timepoint: Before discharge, re hospitalization and after 6 month follow up. Method of measurement: Eco cardiography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAbdulattef Ghazal
Isfahan University of Medical Sciences
Outcome results
None listed