Comparison effect of Topical Dexmedetomidine Infiltration with ?Subcutaneous Ketamine on postoperative Pain in surgery general anesthesia

Comparison effect of topical Dexmedetomidine infiltration with ?subcutaneous Ketamine on postoperative pain in patients candidating ?abdominal hysterectomy under general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016122520258N20

Enrollment

126

Registered

2017-02-21

Start date

2016-12-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal hysterectomy. Prolapse of vaginal vault after hysterectomy

Interventions

Intervention 1: Intervention group: We inject 50 microgram Dexmedetomodine subcutaneous. Intervention 2: Intervention group: We inject 100 milligram Ketamine subcutaneous. Intervention 3: Control grou

Treatment - Drugs

Intervention group: We inject 50 microgram Dexmedetomodine subcutaneous.

Intervention group: We inject 100 milligram Ketamine subcutaneous.

Control group: We inject 5 milliliter normal saline subcutaneous.

Eligibility

Sex/Gender

Female

Age

30 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: ?abdominal hysterectomy; general anesthesia; 30-65 years; duration of surgery maximum 120 minute; ASA I and II Exclusion criteria: allergy for Dexmedetomidine and Ketamine; duration of surgery more than 120 minute; cardiovascular and pulmonary disease

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Mean duration of analgesia?. Timepoint: 2,4 and 8 hours after surgery. Method of measurement: Minute.;Score of pain. Timepoint: 2,4 and 8 hours after surgery. Method of measurement: Visual Analogue Scale Questionnaire.;Amount of Narcotic drug. Timepoint: End of study. Method of measurement: miligeram.;Request narcotic drug. Timepoint: First time for request narcotic. Method of measurement: Minute after surgery.	—

Measure

Time frame

Mean duration of analgesia?. Timepoint: 2,4 and 8 hours after surgery. Method of measurement: Minute.;Score of pain. Timepoint: 2,4 and 8 hours after surgery. Method of measurement: Visual Analogue Scale Questionnaire.;Amount of Narcotic drug. Timepoint: End of study. Method of measurement: miligeram.;Request narcotic drug. Timepoint: First time for request narcotic. Method of measurement: Minute after surgery.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Alireza Kamali

Arak University Of Medical Sciences

alikamaliir@yahoo.com+98 36 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026