Effect of Propolis Extract on Chronic Periodontitis Patients

Comparing The Effect of Propolis Extract and Chlorhexidine Mouthwash on Clinical Parameters and Salivary Level of Matrix Metalloproteinase 8 in Chronic Periodontitis Patients: A Randomized Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016122030475N3

Enrollment

Registered

2017-02-02

Start date

2017-01-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontits. chronic pericoronitis Periodontitis: NOS complex simplex

Interventions

Intervention 1: Intervention group 1: In this group, after SRP, the respective areas will be irrigated with 3cc of hydro-alcoholic solution of propolis extract 20 % (Soren Tech, Mashhad, Iran) twice a

Treatment - Drugs

Intervention group 1: In this group, after SRP, the respective areas will be irrigated with 3cc of hydro-alcoholic solution of propolis extract 20 % (Soren Tech, Mashhad, Iran) twice a week for two w

Intervention group 2: In this group, after SRP, 0.2 % chlorehexidine mouthwash (Shahredaru, Tehran, Iran) is prescribed for use twice a day for two weeks.

Eligibility

Sex/Gender

All

Age

25 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Chronic periodontitis patients; The age range of 25 to 50 years; Having deep periodontal pockets (=5 mm) around a minimum of three teeth not adjacent to each other. Exclusion criteria: Presence of periapical changes in the respective teeth; Systemic conditions requiring antibiotic prophylaxis or affecting the progression of disease or response to treatment; History of periodontal therapy in the past six months; Use of antibiotics, Anti-inflammatory drugs, anticonvulsants, immunosuppressive drugs or calcium channel blockers in the past three months; Pregnancy; Orthodontic treatment; Smoking; Having pacemaker; Mitral valve prolapse, Use of mouthrinses during treatment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical Attachment level (CAL). Timepoint: Before intervention and one month later. Method of measurement: mm using periodontal probe.;Pocket Depth (PD). Timepoint: Before intervention and one month later. Method of measurement: mm using periodontal probe.;Bleeding on probing (BOP). Timepoint: Before intervention and one month later. Method of measurement: positive or negative, using periodontal probe.;Gingival index (GI). Timepoint: Before intervention and one month later. Method of measurement: Average number of teeth with positive bleeding on probing, using periodontal probe.;Matrix Metalloproteinase 8 level of saliva. Timepoint: Before intervention and one month later. Method of measurement: Pg/ml, ELISA TEST.	—

Measure

Time frame

Clinical Attachment level (CAL). Timepoint: Before intervention and one month later. Method of measurement: mm using periodontal probe.;Pocket Depth (PD). Timepoint: Before intervention and one month later. Method of measurement: mm using periodontal probe.;Bleeding on probing (BOP). Timepoint: Before intervention and one month later. Method of measurement: positive or negative, using periodontal probe.;Gingival index (GI). Timepoint: Before intervention and one month later. Method of measurement: Average number of teeth with positive bleeding on probing, using periodontal probe.;Matrix Metalloproteinase 8 level of saliva. Timepoint: Before intervention and one month later. Method of measurement: Pg/ml, ELISA TEST.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactReyhane Eghbali Zarch

School of Dentistry, International Campus, Tehran University of Medical Sciences.

reiihane@yahoo.com+98 21 5585 1131

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 14, 2026