Studying the effects of dexamethasone in the prevention of nausea and vomiting and postoperative pain in patients undergoing abdominal hysterectomy

Comparative study of dexamethasone versus placebo in the prevention of nausea and vomiting and postoperative pain in patients undergoing abdominal hysterectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161220031487N8

Enrollment

102

Registered

2018-04-08

Start date

2016-03-19

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hysterectomy. Acquired absence of genital organ(s)

Interventions

Intervention 1: Intervention group: Single dose of 8 mg intravenous dexamethasone infusion. Intervention 2: Control group: normal saline (2 ml).

Eligibility

Sex/Gender

Female

Age

30 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 30 years Candidate for abdominal hysterectomy Body mass index (BMI) from 20-35

Exclusion criteria

Exclusion criteria: Systemic disease such as diabetes, asthma or cancer History of allergy to dexamethasone Nausea and vomiting in 24 hours prior to operation Receiving anti-emetics 48 hours before operation Digestive system anomalies such as gastritis and esophagitis

Design outcomes

Primary

Measure	Time frame
Prevalence of nausea and vomiting. Timepoint: Measurement at 0? 2? 4? 6? 12 and 24 hours after operation. Method of measurement: The severity of nausea is from 0 to 10, a score of 0 indicates a lack of nausea, and 10 means a very severe nausea.;Severity of pain felt by patients. Timepoint: Measured at 0, 2, 4, 6, 12 and 24 hours after operation. Method of measurement: The severity of the pain felt by the patients is scored from 0 to 10, with zero indicating the absence of pain and 10 means a very severe pain.	—

Measure

Time frame

Prevalence of nausea and vomiting. Timepoint: Measurement at 0? 2? 4? 6? 12 and 24 hours after operation. Method of measurement: The severity of nausea is from 0 to 10, a score of 0 indicates a lack of nausea, and 10 means a very severe nausea.;Severity of pain felt by patients. Timepoint: Measured at 0, 2, 4, 6, 12 and 24 hours after operation. Method of measurement: The severity of the pain felt by the patients is scored from 0 to 10, with zero indicating the absence of pain and 10 means a very severe pain.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahla Amirzargar

Iran University of Medical Sciences

shahlaamirzargar@yahoo.com+98 21 8214 1600

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026