Compare the effects of Avastin and Avastin combined with methylcellulose in intraocular pressure after Non-penetrating glaucoma surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2016121831450N1

Enrollment

Registered

2017-04-18

Start date

2017-02-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glaucoma. Primary open-angle glaucoma Glaucoma (primary)(residual stage): capsular with pseudoexfoliation of lens chronic simple low-tension pigmentary

Interventions

Intervention 1: Intervention group 1: patients in this group will be put under general anesthesia. At first, a fornix-based conjunctival flap is created. Then, a 4x 4 mm outer parabolic flap, approxim

Treatment - Drugs

Intervention group 1: patients in this group will be put under general anesthesia. At first, a fornix-based conjunctival flap is created. Then, a 4x 4 mm outer parabolic flap, approximately 200 µm thi

Intervention group 2: patients in this group will be put under general anesthesia. At first, a fornix-based conjunctival flap is created. Then, a 4x 4 mm outer parabolic flap, approximately 200 µm thi

Eligibility

Sex/Gender

All

Age

40 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion criteria:patients with open-angle glaucoma and uncontrolled IOP on maximally tolerated medical therapy with uncontrolled IOP Exclusion criteria:Patientswith previous glaucoma and cataract surgery,previous surgery due to trauma,angle closure glaucoma, who are less than 40 years? Diabetes;uveitis,Collagen vascular disease,Neovascular glaucoma,end stage glaucoma

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Intraocular pressure. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Goldmann applanation tonometry (mmHg).	—

Secondary

Measure	Time frame
Visual acuity. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Snellen charts.;Visual field. Timepoint: Before surgery, 6 months after surgery. Method of measurement: Humphrey 24-2 SITA Standard perimetry (HFA 24-2) Or(HF30-2).;Beleb morphology. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Moorfields Bleb Grading System.;Endophthalmitis. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Examination slitlamp.;Conjunctival necrosis. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Examination slitlamp.	—

Measure

Time frame

Visual acuity. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Snellen charts.;Visual field. Timepoint: Before surgery, 6 months after surgery. Method of measurement: Humphrey 24-2 SITA Standard perimetry (HFA 24-2) Or(HF30-2).;Beleb morphology. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Moorfields Bleb Grading System.;Endophthalmitis. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Examination slitlamp.;Conjunctival necrosis. Timepoint: Before surgery, 1 day, 3 days, 2 weeks, 4 weeks, 3 months and 6 months after surgery. Method of measurement: Examination slitlamp.

—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactneda moghaddam

Tabriz University of Medical Sciences

ghmoghaddam@tabrizu.ac.ir+98 41 3657 1670

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026