Bipolar I disorder. Bipolar affective disorder, current episode hypomanic
Conditions
Interventions
Intervention 1: Placebo capsule, once a day will start at the baseline and after 3 days will increase to twice a day. In the sixth day, placebo dose will increase to 3 times a day and will continue wi
Placebo
Treatment - Drugs
Placebo capsule, once a day will start at the baseline and after 3 days will increase to twice a day. In the sixth day, placebo dose will increase to 3 times a day and will continue with same dose unt
Memantine 10 mg capsule, once a day will start at the baseline and after 3 days will increase to twice a day. In the sixth day, memantine dose will increase to 3 times a day and will continue with the
Sponsors
Vice Chancellor for Research of Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Between 18 to 60 years old; Meet the criteria for bipolar disorder based on DSM-1V-TR diagnostic criteria and clinical interview by a psychiatrist; Existence of mania, with a minimum score of 20 in Young Mania Rating Scale; Lack of psychiatric diseases; Without mental retardation; Lack of any disease that make a problem in the clinical study; Do not consume narcotic, stimulants and alcohol except nicotine in the three last months; Do not electroconvulsive therapy in the previous month; Not pregnant; Without drug allergy and drug side effects history on the this study drugs; Do not consume memantine in the three last months; Lack of dementia, delirium, cognitive disorders and epilepsy. Exclusion criteria: Drugs side effect that causing discontinuation of consume them; Request by the patient or the patient's parent or legal guardian to withdraw from the study at any time of the study; Consume of alcohol or narcotic by the patient after starting the study; Lack of response to the drug therapy after 2 weeks.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptoms of mania. Timepoint: At the beginning of treatment, second week, forth week and eighth week. Method of measurement: Young Mania Rating Scale Measure. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Alireza Rafiei
Amir Kabir Hospital
Outcome results
None listed