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Effects of glyceryl three nitrate ointment and mefenamic acid capsule on treatment of dysmenorrhea

Comparison the effectiveness of the use of glyceryl three nitrate ointment and mefenamic acid on pain, headache, and gastrointestinal disorders in primary dysmenorrhea women aged 18 to 30 years old without delivery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT2016121311020N9
Enrollment
160
Registered
2017-01-10
Start date
2013-05-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary dysmenorrhea. Primary dysmenorrhoea

Interventions

Intervention 1: Intervention group: Patients use 2.5 mg glyceryl trinitrate ointment for 4 hours on the abdomen skin and under navel for 2 days in three cycles of their menses. Intervention 2: Control
Treatment - Drugs
Intervention group: Patients use 2.5 mg glyceryl trinitrate ointment for 4 hours on the abdomen skin and under navel for 2 days in three cycles of their menses.
Control group: Patients use 250 mg mefenamic acid capsules every 8 hours per day for 48 hours in their three cycles of menses.

Sponsors

Vice chancellor for research, Zahedan University of Medical Science
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 30 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age 18 to 30 years old, primary dysmenorrhea; BMI between 19 and 27; normal ultrasonography, no history of birth Exclusion criteria: Abnormal ultrasound, pelvic and cardiovascular disease, alcohol consumption, drug addiction

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Dysmenorrhea. Timepoint: every 4 hours up to 48 hours after treatment. Method of measurement: VAS.

Secondary

MeasureTime frame
Headache. Timepoint: every 4 hours up 48 hours after treatment. Method of measurement: asking the patient.;Gastrointestinal disorder. Timepoint: every 4 hours up 48 hours after treatment. Method of measurement: asking the patient.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Khooshide

Tehran University of Medical Science

khooshide@yahoo.com+98 21 7771 9922

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026