Coronary Heart Disease. Atherosclerotic cardiovascular disease, so described
Conditions
Interventions
Intervention 1: vitamin d supplement, 50000 IU, 1 time per week for 8 weeks. Intervention 2: placebo, 50000 IU, 1 time per week for 8 weeks.
Treatment - Drugs
vitamin d supplement, 50000 IU, 1 time per week for 8 weeks
placebo, 50000 IU, 1 time per week for 8 weeks
Sponsors
Iran University of Medical Science
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age 30 to 60 years; women and men with coronary heart disease ; Willingness to participate in research exclusion criteria: BMI >35 kg / m2; Vitamin D levels higher than 30 ng / ml; Disease (cancer, myocardial infarction, diabetes, liver problems and kidney); Drugs using out of treatment protocol; Using oral and injectable nutritional supplements for at least the last 4 months (vitamins D, C, E, calcium, magnesium, potassium and multivitamins, omega-3); Using any herbal remedies; Consumption any foods fortified with vitamin D; pregnancy and lactation; Smoking; Alcohol consumption withdraw criteria: Consume less than 7 tablets of 8 tablet at the end of the study ; The occurrence of any event that may affect the health; Any acute illness during the study; Unwillingness to continue cooperation in research
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heat Shock Protein 60. Timepoint: before and 2 month after intervention. Method of measurement: ng/ml by ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical Activity. Timepoint: Before and two months after intervention. Method of measurement: According to MET-minutes / week by 7 days questionnaire of physical activity.;Level of physical activity. Timepoint: Before and two months after intervention. Method of measurement: According to three conditions: light, medium and intense physical activity by 7 days questionnaire.;Sun exposure. Timepoint: Before and two months after intervention. Method of measurement: According to time (minutes) per day using 24 hour recall questionnaire.;Dietary calcium intake. Timepoint: Before and two months after intervention. Method of measurement: mg/day by 24 hour recall questionnaire.;Dietary vitamin d intake. Timepoint: Before and two months after intervention. Method of measurement: unit/day by 24 hour recall questionnaire.;Prothrombin hormone (PTH). Timepoint: Before and two months after intervention. Method of measurement: pg/ml by ELISA.;Energy intake. Timepoint: Before and two months after intervention. Method of measurement: kcal/day by 24 hour recall questionnaire.;Muscle mass and body fat percentage. Timepoint: Before and two months after intervention. Method of measurement: percentage by Beurer devices.;Waist circumference. Timepoint: Before and two months after intervention. Method of measurement: cm by metre.;25(OH)D3. Timepoint: Before and two months after intervention. Method of measurement: nmol/l by ELISA.;Body mass index. Timepoint: Before and two months after intervention. Method of measurement: kg/m2 by Calculate the ratio of the weight by the square of height.;Blood pressure. Timepoint: Before and two months after intervention. Method of measurement: mmHg by Mercury manometers.;Triglyceride. Timepoint: Before and two months after intervention. Method of measurement: mg/dl by Biochemical auto analyzer.;Total cholesterol. Timepoint: Before and two months after intervention. Method of measurement: mg/dl by Biochemical auto analyzer.;High Density Lipoprotein (HDL). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactmohammadreza vafa
Iran university of medical science
Outcome results
None listed