Effect of N-acetyl cysteine on wound healing and oxidative stress biomarkers compared to before treatment in patients with diabetic foot ulcer

Effect of N-acetyl cysteine on wound healing and oxidative stress biomarkers compared to before treatment in patients with diabetic foot ulcer: a before-after clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201612089014N139

Enrollment

Registered

2016-12-15

Start date

2017-01-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetic foot ulcer. Peripheral angiopathy in diseases classified elsewhere

Interventions

Intervention 1: Control group: Just routine treatment. Intervention 2: Intervention group: Routine treatment plus oral N-acetyl cysteine 1200 mg daily for 2 weeks.

Treatment - Drugs

Control group: Just routine treatment.

Intervention group: Routine treatment plus oral N-acetyl cysteine 1200 mg daily for 2 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age of 18 to 65 years; diabetic foot ulcer. Exclusion criteria: pregnancy; breastfeeding; abscess; stomatitis; smoking.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Wound healing. Timepoint: 2 weeks after treatment. Method of measurement: through physical examination.	—

Secondary

Measure	Time frame
Total antioxidant capacity. Timepoint: 2 weeks after treatment. Method of measurement: through laboratory test.;Lipid peroxidase. Timepoint: 2 weeks after treatment. Method of measurement: through laboratory test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoheil Madadi

School of Pharmacy

soheil.madadi@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026