Knee Osteoarthritis. Primary gonarthrosis, bilateral
Conditions
Interventions
Intervention 1: Intervention group:Patients with Knee Osteoarthritis who use nano-curcumin supplementation with resistance training.Exercise groups for 2 months, 3 days a week, knee and hip exercises
Sponsors
Bojnourd University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: Having an OA (primary) knee with a grade of 1 to 4 Low mobility (Participate in sports activities less than three times a week for less than 20 minutes during the past six months and lack of participation in organized activities over the past year) The age range is between 45-60 years Non-acute illness like cardiovascular disease and lack of fracture and injury In the lower extremity or a joint infection Lack of endocrine and metabolic diseases (diabetes, thyroid, kidney, liver), cardiovascular disease (high blood pressure, coronary artery disease and atherosclerosis, peripheral vascular diseases and myocardial infarction), mental illness (depression, Schizophrenia and mania), epilepsy, anemia, cancer and any infectious disease. No history of alcohol and smoking and any addiction
Exclusion criteria
Exclusion criteria: Unwillingness of patients to continue cooperation in research No synovial fluid during aspiration Knee joint limitation and inability to perform sports exercises Any injuries when doing exercises Taking medications other than diclofenac for the treatment of osteoarthritis Suffering from cardiovascular, liver, diabetes, kidney failure Age range less than 45 and more than 60 years Addiction and alcohol and smoking Joint infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of synovial fluid biomarkers of the knee. Timepoint: 24 hours before the intervention and 48 hours after the end of the intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Knee pain. Timepoint: 24 hours before the intervention and 24 hours after the intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index,Visual Analogue Scale.;Improving the quality of life. Timepoint: 24 hours before the intervention and 24 hours after the intervention. Method of measurement: Health Assessment Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarideh Haghighi
Bojnourd University of Medical Sciences
Outcome results
None listed