melasma. Chloasma
Conditions
Interventions
Intervention 1: Intervention group: use of Nanostructured lipid carrier( NLC) nanoparticles containing hydroquinone, tretinoin and fluosinolone made in lab, in patients with moderate to severe melasma
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 18 - 50 years old men and women Case of approximately symmetrical moderate to severe melasma (melasma global severity score(MGSC)>2) No topical and systemic treatment for melasma during the last 4 weeks Appropriate general health condition No change in life style during the study Signing the consent form of the candidate to participate in the study and the desire to attend regular follow-up courses
Exclusion criteria
Exclusion criteria: Pregnant people or those who plan to become pregnant during the study People with known allergies to any of the components of the cream History of using each of the mentioned compounds topically in the last 21 days: Corticosteroids, retinoid compounds, chemical peels, alpha hydroxy acid and beta hydroxy acid compounds History of systemic use of each of the mentioned compounds in the last 28 days: corticosteroids, tretinoin compounds, interferon types Patients with rosacea, skin atrophy, acne and eczema History of use of drugs that increase photosensitivity in the last 3 months People who have had laser skin peeling or microdermabrasion in the last 3 months If the doctor of the study determines that the volunteer is not appropriate for this study by some reaons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified melasma severity index. Timepoint: Before intervention, 4 weeks later, 8 weeks after intervention. Method of measurement: Using mMASI(modified Melasma Severity Index). | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin pH. Timepoint: Before intervention, 4 weeks later, 8 weeks after intervention. Method of measurement: MPA 580.;Skin sebum. Timepoint: Before intervention, 4 weeks later, 8 weeks after intervention. Method of measurement: MPA 580.;Skin melanin and erythem. Timepoint: Before intervention, 4 weeks later, 8 weeks after intervention. Method of measurement: MPA 580.;Trance Epidermal Water Lost (TEWL). Timepoint: Before intervention, 4 weeks later, 8 weeks after intervention. Method of measurement: MPA 580.;Size and value of skin spot. Timepoint: Before intervention, 4 weeks later, 8 weeks after intervention. Method of measurement: Visio face. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaman Ahmad Nasrollahi
Tehran University of Medical Sciences
Outcome results
None listed