Effect of hormonal therapy versus no treatment on testicular histopathology and fertility in patients with non-obstructive azoospermia

Effect of hormonal therapy versus no treatment on testicular histopathology and fertility in patients with non-obstructive azoospermia: a before-after clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201612069014N137

Enrollment

Registered

2016-12-18

Start date

2016-09-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

non-obstructive azoospermia. Male infertility

Interventions

Intervention 1: Intervention group 1: Injection of HCG 5000 U intramuscularly once a week for 10 weeks. Intervention 2: Intervention group 2: Injection of FSH 75 U intramuscularly twice a week for 10

Treatment - Drugs

Intervention group 1: Injection of HCG 5000 U intramuscularly once a week for 10 weeks.

Intervention group 2: Injection of FSH 75 U intramuscularly twice a week for 10 weeks.

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Inclusion criteria: Male; non-obstructive azoospermia; normal sexual hormones. Exclusion criteria: Severe testicular atrophy; varicocele; chromosomal abnormality; sertoli cell syndrome; hypogonadism.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sperm analysis. Timepoint: 10 weeks after treatment. Method of measurement: through laboratory sampling.;Histopathology of testis. Timepoint: 10 weeks after treatment. Method of measurement: trough biopsy.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Farid Tahmoorsi

Shahid Beheshti Hospital

Farbod974@yahoo.com+98 81 3838 0283

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026