COVID-19. the code for the confirmed diagnosis of COVID-19
Conditions
Interventions
Intervention 1: Intervention group 1: patients who will receive standard care plus 4 consecutive doses of intramuscular injection of beta-interferon (each vial contains 30 micrograms of interferon equ
Sponsors
Mashhad University of Medical Sciences
CinnaGen company
Pooyesh Darou company
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult over 18 years Clinical diagnosis of COVID-19
Exclusion criteria
Exclusion criteria: History of allergy to human albumin or interferon
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body temperature. Timepoint: Before intervention, on day of 1 until discharge with 3 day interval. Method of measurement: Thermometer, Celsius.;Respiratory rate. Timepoint: Before intervention, on day of 1 until discharge with 3 day interval. Method of measurement: Pulse oximeter, Breaths per minute.;The ratio of arterial oxygen partial pressure to fractional inspired oxygen. Timepoint: Before intervention, on day of 1 until discharge with 3 day interval. Method of measurement: Ventilator, Millimeter of mercury (mmHg).;Blood gas level. Timepoint: Before intervention, on day of 1 until discharge with 3 day interval. Method of measurement: Blood Gas Analyzer, percent. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lymphocyte count. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: Cell counter, Cell per milliliter.;Lymphocyte count. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: Cell counter, Cell per milliliter.;C-reactive protein level. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: Clinical Biochemistry Analyzer, milligram per deciliter.;Erythrocyte Sedimentation Rate. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: ESR analyzer, millimeter per hour.;Alanine aminotransferase Level. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: Autoanalyzer, Unit per liter.;Aspartate aminotransferase Level. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: Autoanalyzer, Unit per liter.;Total/ conjugated bilirubin levels. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: Autoanalyzer, Milligram per deciliter.;Creatinine. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: Autoanalyzer, Milligram per deciliter.;Creatine kinase myocardial band (CK-MB). Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: Autoanalyzer, international unit per liter.;Troponin. Timepoint: Before intervention, on day of 1 until discharge, with 3 day interval. Method of measurement: enzyme-linked immunosorbent assay, nanogram per mililitere.;Hospitalization time. Timepoint: Admission time until discharge. Method of measurement: ?Day.;Mortality rate. Timepoint: on day of 14 and 28 after intervention. Method of measurement: Mortality formula.;National early warning score 2. Timepoint: On day of 1 and 7 after intervention. Met | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactmaryam Khoshkhui
Mashhad University of Medical Sciences
Outcome results
None listed