Effect of topical versus oral simvastatin as adjuvant therapy for treatment of patients with acne vulgaris

Effect of topical versus oral simvastatin as adjuvant therapy for treatment of patients with acne vulgaris: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201612049014N135

Enrollment

Registered

2016-12-07

Start date

2016-12-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne vulgaris. Acne vulgaris

Interventions

Intervention 1: Intervention group 1: Oral azithromycin 250 mg daily for 8 weeks plus oral simvastatin 40 mg daily for 8 weeks plus topical placebo daily for 8 weeks. Intervention 2: Intervention grou

Treatment - Drugs

Placebo

Intervention group 1: Oral azithromycin 250 mg daily for 8 weeks plus oral simvastatin 40 mg daily for 8 weeks plus topical placebo daily for 8 weeks.

Intervention group 2: Oral azithromycin 250 mg daily for 8 weeks plus oral placebo daily for 8 weeks plus topical simvastatin daily for 8 weeks.

Control group: Oral azithromycin 250 mg daily for 8 weeks plus oral placebo daily for 8 weeks plus topical placebo daily for 8 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age of 18 to 65 years; moderate to severe acne vulgaris based on GAGS criteria for 6 months. Exclusion criteria: pregnancy; breastfeeding; liver disorder; renal disorder; using drug for acne during the last month.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical sign of acne vulgaris. Timepoint: before and 8 weeks after treatment. Method of measurement: using GAGS criteria.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAnahita Ahmadvand

School of Pharmacy

aahmadvand.phun@yahoo.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026