Doxepin cream in reducing knee pain due to Arthritis

Treatment of osteoarthritis of the knee with a topical doxepin: A randomised controlled trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161204031229N7

Enrollment

Registered

2022-04-14

Start date

2022-04-14

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: 'Control group:" The first group received placebo cream Khoramabad University of Medical Sciences? topically 3 times a day with 250-500 mg naproxen capsules for oral use. Intervention

Eligibility

Sex/Gender

All

Age

45 Years to 75 Years

Inclusion criteria

Inclusion criteria: 45_75 years old A definitive diagnosis of osteoarthritis disease with specialist

Exclusion criteria

Exclusion criteria: Severe diseases such as metabolic disorders and digestive at the same time Severe infection Sensitivity to Doxepin cream Pregnancy Lactation Impaired liver function tests History of fracture or knee surgery Rheumatoid arthritis

Design outcomes

Primary

Measure	Time frame
Improving physical Function. Timepoint: Baseline and Six Weeks later. Method of measurement: Western Ontario and McMaster (WOMAC) questionnaire.;Pain relief. Timepoint: Baseline and Six Weeks later. Method of measurement: Visual Analogue Scale (VAS) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzadeh Eshraghi

Iran University of Medical Sciences

eshraghi.a@iums.ac.ir+98 21 8670 2030

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026