The effect of magnesium sulfate in reducing the pain of knee replacement surgery

The Effect of Magnesium Sulphate on Postoperative Pain and Opioid Consumption in Total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161204031229N6

Enrollment

Registered

2022-03-23

Start date

2021-05-22

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: 4 g of magnesium sulfate (equivalent to 8 cc of 50% magnesium sulfate) in 250 cc of normal saline was infused 30 minutes before the operation, during the operation

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: All volunteers for Total knee arthroplasty

Exclusion criteria

Exclusion criteria: Diabetes Renal Disorder Hepatic Disorder Consumption of Calcium Blocker agents Consumption of Magnesium supplements before the study Consumption of Magnesium supplements during the study in the last month magnesium level more than 2.8 Pregnancy Lactation

Design outcomes

Primary

Measure	Time frame
Evaluate the patient's pain. Timepoint: Immediately after surgery, 2, 4, 6, 12 and 24 hours after surgery. Method of measurement: Use visual analogue scale and numerical rating scale.;Serum level of magnesium sulfate. Timepoint: Daily. Method of measurement: Laboratory methods.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzadeh Eshraghi

Iran University of Medical Sciences

aepharm@gmail.com+98 21 6435 2564

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026