Evaluation of the effect of omega-3 supplementation on lipid profile, insulin resistance, inflammatory parameters and SIRT1 in obese children and adolescents, a randmized placebo controlled clinical trial

Evaluation of the effect of omega-3 supplementation on lipid profile, insulin resistance, inflammatory parameters and SIRT1 gene expression in obese children and adolescents, a randmized placebo controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201612014585N10

Enrollment

Registered

2016-12-13

Start date

2016-12-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity. Obesity due to excess calories

Interventions

Intervention 1: Omega 3 supplement 1250 mg/day containing EPA (425 mg) and DHA (325 mg)

oral

once daily for two months. Intervention 2: placebo

taken as tablet once a day for 2 consecutive months.

Treatment - Drugs

Placebo

Omega 3 supplement 1250 mg/day containing EPA (425 mg) and DHA (325 mg)

once daily for two months

placebo

taken as tablet once a day for 2 consecutive months

Eligibility

Sex/Gender

All

Age

8 Years to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: BMI above 95th percentile for the specific age and gender healthy and not having any disease not taking medications specially those that interfere with lipid and carbohydrate metabolism Exclusion criteria: BMI between 85th and 95th percentile BMI lower than 5th percentile taking medications having any other disease other than obesity

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Insulin resistance. Timepoint: 60 days. Method of measurement: HOMA-IR index.;Inflammatory markers. Timepoint: 60 days. Method of measurement: ELISA.;Sirtuin 1 gene expression. Timepoint: 60 days. Method of measurement: Real-time PCR.;Lipid profile. Timepoint: 60 days. Method of measurement: calorimetric.	—

Secondary

Measure	Time frame
Body mass index. Timepoint: 60 days. Method of measurement: weight/height*height.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mona Nourbakhsh

H. Aliasghar hospital

drmnrbh@yahoo.com+98 21 2222 2042

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026