Chronic Diabetic Foot Ulcer. Insulin-dependent diabetes mellitus with other specified complications
Conditions
Interventions
Intervention 1: Study group: Daily injection of 40 mg of low-molecular weight heparin during 30 days. Intervention 2: Control group: Daily injection of 0.2 ml of normal saline during 30 days.
Treatment - Drugs
Study group: Daily injection of 40 mg of low-molecular weight heparin during 30 days
Control group: Daily injection of 0.2 ml of normal saline during 30 days
Sponsors
Guilan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1- Recent chronic neuropathic diabetic foot ulcer (less than 10 days) 2- Ulcer Wagner grade is 1 or debrided patients or limited amputation with Wagner grade of 2, 3, and 4 3- ABI > 0.9 (not ischemic and neuroischemic) 4- Open or debrided ulcer or limited amputation 5- Having informed consent for study inclusion Exclusion Criteria 1- Chronic diabetic foot ulcers caused by ischemia 2- Under treatment with anticoagulant therapy at the time of study inclusion 3- contraindication of low molecular weight heparin administration, including severe renal failure (creatinine lower than 30 ml/min (hepatic failure of Child-Pugh class B or C, having bleeding disorders and proliferative diabetic retinopathy subject to bleeding risk 4- Active osteomyelitis 5- Systemic sepsis
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diabetic Foot Ulcer. Timepoint: every 10 days in 30-day period. Method of measurement: Digital imaging. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Milad Sarrafi
Guilan University of Medical Sciences
Outcome results
None listed