Major Depressive Disorder.
Conditions
Interventions
Intervention 1: Control, Placebo. Intervention 2: Intervention, Multi species Probiotic capsules containing 3×109 CFU Lactobacillus Helveticus and Bifidbacterium Longum.
Placebo
Treatment - Drugs
Intervention, Multi species Probiotic capsules containing 3×109 CFU Lactobacillus Helveticus and Bifidbacterium Longum
Sponsors
Vice chancellor for research, Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
77 Years to 30 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria:patients with Major Depressive based on DSM-IV-TR criteria that they have not used any nutritional supplements, antiinflammatory and antidepressant drugs at least 2 months prior to intervention; aged 18 to 65 years; at least score 15 on Hamilton Depression Rating Scale 17 (HDRS-17). Exclusion Criteria: pregnancy and lactation; drug abuse within 6 months prior to intervention; psychosis; any type of severe chronic physical illness; any extreme and severe mental disorders (suicidal ideation, psychotic symptoms, symptoms of manic phase, etc); compliance rate less than% 80; consuming probiotic foods during intervention.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Catalase. Timepoint: Begining and end of intervention. Method of measurement: Colorimetry.;Homocystein. Timepoint: Begining and end of intervention. Method of measurement: ELIZA.;Oxidized -LDL. Timepoint: Begining and end of intervention. Method of measurement: ELIZA.;MDA. Timepoint: Begining and end of intervention. Method of measurement: Colorimetry.;Arylstrase activity of Paraxonase. Timepoint: Begining and end of intervention. Method of measurement: Colorimetry.;Hs-CRP. Timepoint: Begining and end of intervention. Method of measurement: ELIZA.;Fibrinogen. Timepoint: Begining and end of intervention. Method of measurement: Coagulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Energy intake. Timepoint: Begining and end of intervention. Method of measurement: 24-hour recall.;Physical activity. Timepoint: Begining and end of intervention. Method of measurement: IPAQ questionnaire.;Side effect. Timepoint: End of forth week and end of intervention. Method of measurement: Side effect questionnaire.;Weight. Timepoint: Begining and end of intervention. Method of measurement: Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShirin Tajadod
Department of Nutrition, School of Public Health, Iran University of Medical Sciences.
Outcome results
None listed