Primary gonarthrosis, bilatera. Primary gonarthrosis, bilateral
Conditions
Interventions
Intervention 1: Intervent group: ozon injection will be performed under the ultrasound guid in the knee joint which will be done by an experienced physical medicine and rehabilitation specialist
using supra patellar approach. Intervention 2: Control group: corticosteroid injection will be performed under the ultrasound guid in the knee joint which will be done by an experienced physical medi
Treatment - Other
Intervent group: ozon injection will be performed under the ultrasound guid in the knee joint which will be done by an experienced physical medicine and rehabilitation specialist
Control group: corticosteroid injection will be performed under the ultrasound guid in the knee joint which will be done by an experienced physical medicine and rehabilitation specialist
Sponsors
Vice President of Research Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients with mild to moderate OA of the knee (Kellgren Lawrence grade I, II and III); Knee pain for at least six months; Age 40 to 75 years; the absence of any acute or chronic infection; no pregnancy or lack of planning to get pregnant; no history of any intra articular knee injection in three months ago; The absence of inflammatory articular disease or secondary osteoarthritis; no history of knee surgery (3 months ago); no severe underlying disease such as uncontrolled diabetes; use of anticoagulants; lack of daily use of opioid and non opioid analgesics; absence of contraindications of ozone therapy (deficiency G6PD, uncontrolled hyperthyroidism, leukemia). Exclusion criteria: the willingness of patients to exit from the study at any stage of the study; not coming patients for follow up and evaluation during the follow up period; daily use of any type of analgesic medication by patients during the follow up period; occurring a pathology in the knee, such as meniscus tear during the follow up period; occurring 4th and 7th inclusion criteria, during the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The severity of pain. Timepoint: Zero, one, four and twelve weeks after. Method of measurement: Visual Analog Scale(VAS).;The severity of symptoms and functional limitations. Timepoint: Zero, one, four and twelve weeks after. Method of measurement: By using WOMAC questionnare.;Sonographic criteria (efusion). Timepoint: Zero, one, four and twelve weeks after. Method of measurement: By using sonographic device.;Range of motion. Timepoint: Zero, one, four and twelve weeks after. Method of measurement: Goniometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: One and four weeks after. Method of measurement: Physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Saeideh najarzadeh mehdikhani
Iran University of Medical Sciences
Outcome results
None listed