Comparison of the effect of dexmedetomidine and propofol on how patients sleep after cardiac surgery

Comparison of the effect of sedation with dexmedetomidine and propofol on sleep quality in patients after cardiac surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161127031131N3

Enrollment

118

Registered

2022-05-09

Start date

2021-05-22

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with coronary artery disease. Acute coronary thrombosis not resulting in myocardial infarction

Interventions

Intervention 1: Control group: Propofol group: in this group we will infuse 50 µg/kg/min propofol in 6 hours (before the time of extubation ).The RASS will use to assess patients’ levels of sedatio

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: cardiovascular surgery aged above 18 years

Exclusion criteria

Exclusion criteria: If patients received both dexmedetomidine and propofol concomitantly for the primary sedation or an alternative agent as the primary sedation Prior solid organ transplant Pregnant patients Lactating patients

Design outcomes

Primary

Measure	Time frame
Evaluation of patient satisfaction with sedation during intubation. Timepoint: The drugs used will start after patients start to wake up, and 4-6 hours before the time of extubation in both groups .The Richmond Agitation and Sedation Scale (RASS) and Mary's Hospital Sleep Questionnaire used the day after operation in ICU. Method of measurement: The Richmond Agitation and Sedation Scale (RASS) and Mary's Hospital Sleep Questionnaire and vital sign and patients lab data.	—

Measure

Time frame

Evaluation of patient satisfaction with sedation during intubation. Timepoint: The drugs used will start after patients start to wake up, and 4-6 hours before the time of extubation in both groups .The Richmond Agitation and Sedation Scale (RASS) and Mary's Hospital Sleep Questionnaire used the day after operation in ICU. Method of measurement: The Richmond Agitation and Sedation Scale (RASS) and Mary's Hospital Sleep Questionnaire and vital sign and patients lab data.

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Secondary

Measure	Time frame
The effect of sedation on analgesia after extubation. Timepoint: Based on the Richmond Agitation and Sedation Scale (RASS), and Mary's Hospital Sleep Questionnaire (SMHSQ)which is a valid and reliable method for assessing patient sedation in the intensive care unit. And completing the questionnaire the next day. Method of measurement: Richmond Agitation and Sedation Scale (RASS), and Mary's Hospital Sleep Questionnaire (SMHSQ) and completing a questionnaire on the duration of intubation and intensive care drugs like inoteropes.	—

Measure

Time frame

The effect of sedation on analgesia after extubation. Timepoint: Based on the Richmond Agitation and Sedation Scale (RASS), and Mary's Hospital Sleep Questionnaire (SMHSQ)which is a valid and reliable method for assessing patient sedation in the intensive care unit. And completing the questionnaire the next day. Method of measurement: Richmond Agitation and Sedation Scale (RASS), and Mary's Hospital Sleep Questionnaire (SMHSQ) and completing a questionnaire on the duration of intubation and intensive care drugs like inoteropes.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Ghadimi

Iran University of Medical Sciences

m_ghadimi@sums.ac.ir+98 21 2392 2417

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026