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A comparative study of fluid therapy with Ringer's and Ringer's lactate solution on acid and base status and blood electrolytes in patients with coronary artery bypass graft surgery

Comparison of the effect of fluid therapy with Ringer and Ringer lactate solution on acid and base status and blood electrolytes in patients with coronary artery bypass graft surgery

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20161127031131N2
Enrollment
160
Registered
2021-11-16
Start date
2021-10-23
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Use of Ringer lactate serum.

Interventions

Intervention 1: Intervention group: After applying the principles of randomization and placing the patient in the intervention group and transferring the patient to the operating room, the necessary

Sponsors

Rajaei Cardiovascular Medical and Research Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Age 30 to 70 years - 2.Weight 30 to 100 kg 3. No license for severe kidney or liver disease (creatinine more than 1.5 and liver enzymes more than 2 times normal) 4. Absence of severe heart failure (LVEF> 35%)

Exclusion criteria

Exclusion criteria: 1. Cardiac arrest of the patient during surgery or on the first day in the intensive care unit, 2. Severe postoperative bleeding on the first day (more than 1000 ml) in the intensive care unit 3. The patient returns to the pump for any reason 4. Intra-aortic implantation of a balloon pump or ECMO for any reason 5.Transfer of the patient to the intensive care unit with an open sternum 6. Need for high-dose inotropes (epinephrine or norepinephrine greater than 0.2 micrograms per kilogram of body weight per minute)

Design outcomes

Primary

MeasureTime frame
1.level of lactate. Timepoint: 1. When the patient enters the operating room 2. After induction of anesthesia 3. Time off from the pump 4.Upon entering the ICU 5.Until the hour after entering the ICU 6.12 hours after entering the ICU 7.18 hours after entering the ICU. Method of measurement: Arterial blood sample and blood gas analyzer.

Secondary

MeasureTime frame
Level of Sodium,. Timepoint: 1. When the patient enters the operating room 2. After induction of anesthesia 3. Time off from the pump 4.Upon entering the ICU 5.Until the hour after entering the ICU 6.12 hours after entering the ICU 7.18 hours after entering the ICU. Method of measurement: Arterial blood sample and blood gas analyzer.;Level of Potasium. Timepoint: 1. When the patient enters the operating room 2. After induction of anesthesia 3. Time off from the pump 4.Upon entering the ICU 5.Until the hour after entering the ICU 6.12 hours after entering the ICU 7.18 hours after entering the ICU. Method of measurement: Arterial blood sample and blood gas analyzer.;Acidose. Timepoint: 1. When the patient enters the operating room 2. After induction of anesthesia 3. Time off from the pump 4.Upon entering the ICU 5.Until the hour after entering the ICU

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRasool Azarfarin

Iran University of Medical Sciences

razarfarin@yahoo.com+98 21 2392 2017

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026