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Comparison of the effect of adding dexmedetomidine with dexamethasone to bupivacaine in abdominal transverse block on pain intensity after laparoscopic cholecystectomy

Comparison of the effect of adding dexmedetomidine with dexamethasone to bupivacaine in abdominal transverse block on pain intensity after laparoscopic cholecystectomy

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20161126031095N4
Enrollment
100
Registered
2023-06-24
Start date
2023-06-26
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Other acute postprocedural pain. Other acute postprocedural pain

Interventions

Intervention 1: Control group: Patients received 17 ml of 0.25% bupivacaine + 3 ml of 0.9% saline in a total volume of 20 ml on each side. Intervention 2: Intervention group: Patients received 17 ml o

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ASA class I and II physical condition Age between 18-65 years

Exclusion criteria

Exclusion criteria: Patient refusal to participate Neuromuscular diseases (eg myopathy, myasthenia gravis) Hematological diseases, bleeding or coagulation disorders Local skin infection and sepsis at the block site Known hypersensitivity to study drugs Morbid obesity (BMI > -35.7 History of alcoholism or drug addiction Any uncompensated systemic disease (cardiovascular, respiratory, metabolic, neurological and endocrine) Other mental or emotional problems that may invalidate informed consent. Patients will be screened by a preoperative care nurse. Potentially eligible individuals will be directed to investigators for screening and additional information. Sleep apnea or any other sleep disorder

Design outcomes

Primary

MeasureTime frame
Severity of patients' pain. Timepoint: zero, 2, 4, 6, 12 and 24 hours after the operation. Method of measurement: Visual Analogue Scale.;Sedation score. Timepoint: zero hours 2, 4, 6, 12 and 24 after the operation. Method of measurement: Reverse Observer Assessment Scale of Consciousness/Sedation (OAA/S).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlieh Zamani Kiasari

Mazandaran University of Medical Sciences

aliehzamani@yahoo.com+98 11 3335 5080

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026