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Comparison of the additive effect of dexmedetomidine and neostigmine to bupivacaine on pain intensity after cesarean section with spinal anesthesia

Comparison of the additive effect of dexmedetomidine and neostigmine to bupivacaine on pain intensity after cesarean section with spinal anesthesia

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20161126031095N2
Enrollment
110
Registered
2021-07-13
Start date
2020-11-21
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Other acute postprocedural pain. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group1: 1 microgram of dexmedetomidine is equivalent to a volume of 0.5 ml plus 2.5 ml of 0.5% bupivacaine. As a result, the total injection volume in each sample is 3 ml,

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Women who have had a cesarean delivery

Exclusion criteria

Exclusion criteria: Patients who have refused to participate Drug addiction Have underlying diseases (moderate or severe heart, kidney, lung or nerve disease, significant scoliosis, kyphosis, obesity or blood clotting disease) Patients with a height of less than 130 cm or aBody mass Index ( BMI) of more than 35

Design outcomes

Primary

MeasureTime frame
Pain after cesarean section. Timepoint: Hours 0, 2, 4, 8 and 12. Method of measurement: According to the Visual Analogue Scale criteria.

Secondary

MeasureTime frame
Sedation. Timepoint: 0,2,4,8,12. Method of measurement: Ramsay Criteria.;Immobilization. Timepoint: 0,2,4,8,12. Method of measurement: Bromage scale.;Moderate arterial blood pressure. Timepoint: 0,2,4,8,12. Method of measurement: Checklist.;Oxygen saturation. Timepoint: 0,2,4,8,12. Method of measurement: pulse oximetry.;Apgar score. Timepoint: 0,2,4,8,12. Method of measurement: Checklist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactIman Asdaghi Jahromi

Mazandaran University of Medical Sciences

Iman.asdaghi@gmail.com+98 11 3335 5080

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026