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Effect of mannitol and hypertonic saline on brain tumor

Evaluation of effect of preoperative infusion of mannitol vs hypertonic saline on ICP and inflammatory biomarkers in brain tumor patients undergo craniotomy at Sina hospital,a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20161126031091N2
Enrollment
60
Registered
2018-09-11
Start date
2017-09-23
Completion date
Unknown
Last updated
2018-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain tumor. G96.9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.

Interventions

Intervention 1: patients in intervention group received 2-3 meq/kg hypertonic saline 5%. they were taken a blood sample (about 3 cc) before being administered hypertonic saline and 72 hours after the

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Supratentorial brain tumor patients without history of craniotomy New onset brain tumor Age above 18 and under 80

Exclusion criteria

Exclusion criteria: Metastatic brain tumor Renal failure ( Cr>1.5) Nephrotic syndrome Heart rate <60 Diabetes melitus Severe cardiopulmonary disorders Uncontrolled high blood pressure Age under 18 and above 80 Glasco Coma Scale under 6

Design outcomes

Primary

MeasureTime frame
S100B (a biomarker). Timepoint: operation day(before infusion of osmotic fluid) and 72 hours after surgery. Method of measurement: S100B mesuring with ELISA kit(Biovender).

Secondary

MeasureTime frame
Urine output (ml) during the operation. Timepoint: at the end of the operation. Method of measurement: by measuring of urine output collected in urine bag.;Bleeding volume(ml) during operation. Timepoint: at the end of the operation. Method of measurement: by measuring of bottle and used gauzes during the surgery.;Operating time. Timepoint: at the end of the operation. Method of measurement: by measuring time based on hours and minutes of start and end of operation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Babaie

Tehran university of medical sciences

mhs.babaie@student.tums.ac.ir00

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026