Comparison the effect of distilled water and normal saline on hemodynamic parameters and ventilator associated pneumonia

Comparison the effect of distilled water and normal saline instillation during endotracheal suctioning on hemodynamic parameters and ventilator associated pneumonia among patients under mechanical ventilation

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20161124031068N2

Enrollment

Registered

2018-10-20

Start date

2017-11-22

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator associated pneumonia (VAP). Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group: Instillation of 3 to 5 cc of distilled water (Samen company, Iran) in the trachea before endotracheal suctioning for 5 continuous days by nurse. Intervention 2: Con

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Negative culture of the trachea at the beginning of intubation Systolic blood pressure more than 90 mmHg without administration of inotropic drugs Normal level of electrolytes Without cardiac arrhythmia Urinary output more than 30 cc per hour Without asthma Without chronic obstructive pulmonary disease Without lung infections

Exclusion criteria

Exclusion criteria: With previous asthma With previous chronic obstructive pulmonary disease With previous lung infections

Design outcomes

Primary

Measure	Time frame
Ventilatore associated pneumonia. Timepoint: Before intervention and 5 days after intervention. Method of measurement: Endoteracheal culture.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Before and 5 minutes after endotracheal suctioning. Method of measurement: Vital-signs monitoring device.;Heart rate. Timepoint: Before and 5 minutes after endotracheal suctioning. Method of measurement: Vital-signs monitoring device.;Respiratory rate. Timepoint: Before and 5 minutes after endotracheal suctioning. Method of measurement: Vital-signs monitoring device.;Peripheral blood oxygen saturation (SpO2). Timepoint: Before and 5 minutes after endotracheal suctioning. Method of measurement: pulse oximeter.	—

Measure

Time frame

Blood pressure. Timepoint: Before and 5 minutes after endotracheal suctioning. Method of measurement: Vital-signs monitoring device.;Heart rate. Timepoint: Before and 5 minutes after endotracheal suctioning. Method of measurement: Vital-signs monitoring device.;Respiratory rate. Timepoint: Before and 5 minutes after endotracheal suctioning. Method of measurement: Vital-signs monitoring device.;Peripheral blood oxygen saturation (SpO2). Timepoint: Before and 5 minutes after endotracheal suctioning. Method of measurement: pulse oximeter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Esmaeili

Tehran University of Medical Sciences

Esmaeiliem@yahoo.com+98 21 6692 7171

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026